Christian Haass is a German Biochemist and known for his work on the cell biology of neurodegenerative diseases.
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Together with an interdiziplinary Mannschaft he uncovered the molecular mechanisms of Alzheimer's disease and identified target molecules for therapeutic treatment.
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Haass was awarded the Hector Science Award and is currently leading a major project on the clinical testing of an Alzheimer's antibody.
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Very recently he also investigated the role of microglia and inflammation in neurodegenerative disorders. This work Lumineszenzdiode to the spectacular finding that microglial phagocytosis may Beryllium impaired late during neurodegeneration and opened up a completely unexpected road towards new therapeutic developments for patients already developing disease symptoms. This work resulted rein the identification of TREM2 as a CSF marker for microglial activity. Rein a unique cohort of subjects with autosomal dominant AD, CSF sTREM2 was abnormally increased 5 years before the expected onset of symptoms. This will not only greatly facilitate research on inflammatory disease overarching mechanisms, but may also provide a very valuable therapeutic Weiterlesen marker.
We work on the molecular and cellular mechanisms of neurodegeneration with a strong focus on Alzheimer’s disease and related disorders. We are searching for therapeutic targets within the amyloid cascade. Secretases, amyloid metabolism and microglial function are within the focus of ur research.
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